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When neutrophils are released into circulation, they are already fully equipped with an assortment of weapons against a wide range of infectious pathogens including bacteria, fungi and protozoan parasites [75]. If microorganisms manage to pass through the physical and chemical barriers provided by the skin, mucous membranes and endothelia throughout the human body, neutrophils become rapidly attracted to the site of infection. Once arrived, they kill pathogens through phagocytosis, production of ROS/RNS and the formation of NETs (Fig. 1).
Fig. 1
figure 1
Neutrophil strategies to kill invading pathogens. Neutrophils are equipped with multiple weapons against pathogens, such as bacteria (light green) including uptake into phagosomes (phagocytosis). Subsequently, pathogens are degraded in the phagosome by several means. These include reactive oxygen and nitrogen species (ROS/RNS) generated by NADPH oxidase (NOX2) and inducible nitric oxide synthase (iNOS) as well as the release of antimicrobial effectors [i.e. neutrophil elastase (NE; orange), myeloperoxidase (MPO; blue), lysozyme and other degradative enzymes (brown)] into the phagosome (degranulation), and the formation of neutrophil extracellular traps (NETs). The NETs themselves are associated with antimicrobial proteins including histones, and the aforementioned NE and MPO. Inside the phagolysosome MPO reacts with H2O2 to form Compound I, the most oxidatively reactive state of MPO. Compound I can then react with an electron-rich organic substrate (RH) to form radical species (R·) and Compound II. Compound II subsequently reacts with another substrate (RH) to return to the native state of the MPO, completing the peroxidation cycle. But much more importantly, in the halogenation cycle (pseudo-)halide ions (X−) such as chloride (Cl−), bromide (Br−) or thiocyanate (SCN−) are oxidized by Compound I to yield the respective hypohalous acids (HOX), HOCl, HOBr or HOSCN, directly regenerating native MPO
https://link.springer.com/article/10.1007/s00018-020-03591-y?utm_source=substack&utm_medium=email
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About Jeffrey Prather
Retired Special Operations Soldier, former DIA Intelligence Collector, and ex-DEA Special Agent, Jeffrey Prather, delivers situational awareness and breaks down what’s coming for freedom-loving patriots.
Targeted by the Deep State, Jeffrey became a whistle-blower and refocused his mission to serve you with...
DHS denied Trump's Secret Service detail requested additional support. After the official Republican nomination Trump's detail would be increased automatically. Assassin struck prior to that, and, snuck into mid-concentric circle security, highly likely farmed out to locals roving police patrols. Majority of police have no training and are poor at diplomatic security.
FBI brings in evidence teams after releasing eye witnesses, and it is all filmed.
THIS WAS PLANNED! -JP
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